Very encouraging. n.b.: I wish we could return to "inflation" as an increase in the money supply, creating higher prices, rather than just any price rise being an inflation (of prices, I guess,) and irrespective of it's cause.
Where I live there's been something of a "Dunkirk to Normandy" reversal of police presence and activity, especially with regards to traffic safety enforcement. Maybe this time the D in D-Day is for Donut, as in, the Dunkirk-like Retreat to the Donut Shop has been reversed to a Deployment From The Donut Shop. With the next generations of GLP1 Agonist miracle drugs coming out, it's probably the end of the Donut Shop era in both the metaphorical and literal senses. It's now entirely plausible that obesity in America will not just stabilize but decrease significantly every year from now on. This will especially be true when so many people look thin that being fat becomes like smoking cigarettes in public and too low status and shunned for people to resist the negative social pressure to lose weight.
Like most attempts to put subcutaneously-applied medicines into oral pills, results are pretty disappointing, require lots more substance, with lots more metabolites with related increase in side-effects. First-pass metabolism issues really are a bitch. The shots are really nothing, tiny pricks with insulin gauge needles.
People are already getting 3rd generation stuff from China via gray market for only $10-$20 a week, which, given the benefits, is crazy cheap. There is just no contest whatsoever between the ease and speed of weight loss via these agonists compared to the old fashioned way.
When I was in training we were told generics are essentially equivalent to brand names and subject to the same FDA rigor. With the entry of foreign generics makers (India in particular) I am no longer confident that is true. I recently switched my dog from generic to brandname Rimadyl for his joints and the difference was huge (anecdotal and it could be placebo effect on my part but that's what I saw)
Chemical synthesis of drugs is almost always a standard industrial process that benefits from huge economies of scale with negligible marginal costs and with outputz which are easy to test with cheap modern analytics equipment for purity up to many sigmas of quality assurance. Often times the core active substances are literally produced in the same mega-facilities with only branding and mostly unimportant tinkering being the only distinction between brand name and generic. The potential markup for brand favoritism is so much that the companies have a bad incentive to get right up to the legal lines to encourage people to believe otherwise.
You ain't seen nothing yet. I think there are about 20 million Americans using currently, and I predict this rises to 100 million by 2030. The only reason Novo Nordisk isn't worth even more and single-handedly responsible for Danish employment and GDP growth is because now they've got serious competition. Wegovy / Ozempic is semaglutide (1st gen) but Eli Lily has already released terzepitide (2nd gen) and is finishing up trials for the truly incredible 3rd gen retatrutide. I'm not exaggerating at all when I refer to it as a true miracle drug. It and other similar substances are going to be genuinely revolutionary. Bye bye 'People of Walmart'. In terms of waistlines, pictures of 2030s Americans are going to look like pictures of 1960s Americans. Like a lot of current AI breakthroughs, very few saw that coming even as recently as 10 years ago.
Those are some really large swings in traffic deaths, both positive and negative. How can that be explained?
So, not only are deaths of exhuberance down, but thefts of exhuberance are down as well. Now if we can just get the trannies in line...
Very encouraging. n.b.: I wish we could return to "inflation" as an increase in the money supply, creating higher prices, rather than just any price rise being an inflation (of prices, I guess,) and irrespective of it's cause.
Where I live there's been something of a "Dunkirk to Normandy" reversal of police presence and activity, especially with regards to traffic safety enforcement. Maybe this time the D in D-Day is for Donut, as in, the Dunkirk-like Retreat to the Donut Shop has been reversed to a Deployment From The Donut Shop. With the next generations of GLP1 Agonist miracle drugs coming out, it's probably the end of the Donut Shop era in both the metaphorical and literal senses. It's now entirely plausible that obesity in America will not just stabilize but decrease significantly every year from now on. This will especially be true when so many people look thin that being fat becomes like smoking cigarettes in public and too low status and shunned for people to resist the negative social pressure to lose weight.
I’m amazed by how many people are on the shot.
I probably should be but it still costs so much and I keep thinking I can do it the old fashioned way again.
Just wait a year, the pill version is coming soon
I might jump on that. I just want a few more years to see if dead bodies start piling up.
Like most attempts to put subcutaneously-applied medicines into oral pills, results are pretty disappointing, require lots more substance, with lots more metabolites with related increase in side-effects. First-pass metabolism issues really are a bitch. The shots are really nothing, tiny pricks with insulin gauge needles.
People are already getting 3rd generation stuff from China via gray market for only $10-$20 a week, which, given the benefits, is crazy cheap. There is just no contest whatsoever between the ease and speed of weight loss via these agonists compared to the old fashioned way.
When I was in training we were told generics are essentially equivalent to brand names and subject to the same FDA rigor. With the entry of foreign generics makers (India in particular) I am no longer confident that is true. I recently switched my dog from generic to brandname Rimadyl for his joints and the difference was huge (anecdotal and it could be placebo effect on my part but that's what I saw)
Chemical synthesis of drugs is almost always a standard industrial process that benefits from huge economies of scale with negligible marginal costs and with outputz which are easy to test with cheap modern analytics equipment for purity up to many sigmas of quality assurance. Often times the core active substances are literally produced in the same mega-facilities with only branding and mostly unimportant tinkering being the only distinction between brand name and generic. The potential markup for brand favoritism is so much that the companies have a bad incentive to get right up to the legal lines to encourage people to believe otherwise.
You ain't seen nothing yet. I think there are about 20 million Americans using currently, and I predict this rises to 100 million by 2030. The only reason Novo Nordisk isn't worth even more and single-handedly responsible for Danish employment and GDP growth is because now they've got serious competition. Wegovy / Ozempic is semaglutide (1st gen) but Eli Lily has already released terzepitide (2nd gen) and is finishing up trials for the truly incredible 3rd gen retatrutide. I'm not exaggerating at all when I refer to it as a true miracle drug. It and other similar substances are going to be genuinely revolutionary. Bye bye 'People of Walmart'. In terms of waistlines, pictures of 2030s Americans are going to look like pictures of 1960s Americans. Like a lot of current AI breakthroughs, very few saw that coming even as recently as 10 years ago.
I hope you're right. Every past miracle cure for obesity has turned out to have terrible consequences.
Good Lord, I had no idea. Perhaps we’ll go right back to the days of being fat as a signifier of wealth.
Wasn't the car theft because new and used car prices shot up during the pandemic?
Why did homeowner's insurance jump so high the last 5 years? More claims or the cost of construction?